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KMID : 0363219750130010005
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Korean Journal of Dermatology
1975 Volume.13 No. 1 p.5 ~ p.7
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Treatment of Hyperpigmented Diseases with 4-Isopropylcatechol.
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卞東吉/Byun, Dong Gil
金貞會/朴洋子/李順福/Kim, Joung Hoe/Park, Yang Ja/Lee, Soon Bok
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Abstract
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Disfiguring hyperpigmentation of the exposed areas may have important and lasting effects on the emotional well-being of the patient. And many attempts to treat areas of hyperpigmentation have been carried out, but all of them are not very successful. Recently 4-isopropylcatechol has been known to inhibit melanin pigmentation with a selective action on melanocytes either destroying or inactivating the melanocytes experimentally.. There is no report on it´s´ clinical trial till now.
In this study, 1% 4-isopropyicatechol cream was topically applied to the hyperpigmented lesions of 29 patients of melasma, freckle, and cafe-au-lait spot. The bleaching effect onmelasmas was very satisfactory in all patients but contact dermatitis in 3 patients and reticular hyperpigmentation with areas of depigmented spots in one patient were developed as the side effects of the drug. Freckle and cafe-au-lait spots were not bleached.
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